Mrs. Claus is Santa Claus's wife. Due to an incident where Santa had been kissed under mistletoe by a mother, Mrs. Claus would only let him deliver presents when everyone was asleep.
Unknown to the world, Santa had been abducted by Zinyak. This was covered up by Mrs. Claus and the elves for the greater good. With the Christmas Spirit still strong, the North Pole carried on as if nothing had happened. Due to her reindeer dander allergy, she was unable to deliver the presents, so an elf named Twinkle took that role. Unfortunately, the mental damage inflicted on Santa by the Zin eventually turned Santa into a twisted, holiday-hating monster named Clawz that assaulted the North Pole. Mrs. Claus fought to defend the Toy Factory with extreme firepower and was saved by the arrival of Playa, a time traveling Future Shaundi and a freed Santa.
- She is the first Mythological figure to be unlocked in the Saints Row series.