Mayhem may refer to:
- Mayhem - the general activity through the Saints Row games
- Tank Mayhem - the mayhem activity in Saints Row: The Third and Saints Row IV that involves driving a Challenger
- Mech Suit Mayhem - the mayhem activity in Saints Row IV that involves wearing a mech suit
- TK Mayhem - the mayhem activity in Saints Row IV that involves throwing alien wrecking balls
- UFO Mayhem - the mayhem activity in Saints Row IV that involves driving an alien UFO Void